Simple Pharmanotes

  Important Questions for First Sessional Examination . Long Questions: Explain the significance of controlled release systems and their design. Explain the physiological and biochemical features of Controlled Drug Delivery Systems . Answer :: Definition : Controlled drug delivery is one which delivers the drug at a predetermined rate, locally or systemically, for a specified period of time. However it is observed that many terms are used synonymously, to differentiate them from one another we are going to discuss different terminologies that are used in NDDS related to controlled release formulations. Rationale : To provide a location-specific action within the GIT. To avoid an undesirable local action within the GIT. To provide a programmed drug delivery pattern. To increase the rate and extent of absorption/bioavailability. To extend the duration of action of the drug. Significance : Maintains the drug level within the desired range. Useful for delivery of "difficult"’ dru