Synthesis and Significance of 5-HT: Also called “ Serotonin ”. There are three main types of cells that store serotonin ( 5-hydroxytryptamine ) - Blood platelets Neurons in the brain and the intestinal myenteric plexus, Mucosa of the gastrointestinal tract contains enterochroma ffi n cells. The enterochromaffin cells and serotonergic neurons produce serotonin from L-tryptophan, Platelets uptake the serotonin from blood . In the cytosol of brain cells , the enzyme L-tryptophan hydroxylase (TPH) is involved in the synthesis of serotonin through the conversion of L-tryptophan to 5-hydroxytryptophan. Serotonin synthesis in neurons is regulated by this enzyme in a similar fashion to that by the related enzyme L-tyrosine hydroxylase, which converts L-tyrosine to L-dihydroxyphenylalanine (L-DOPA). Functions of Serotonin: Mood elevator. Involved in bone metabolism. Involved in cardiovascular health. Involved in eye health. Involved in blood clotting. Involved in neuro...
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