Skip to main content

Renin Angiotensin Mechanism.

Mixing: Mechanisms of Mixing.

 

Definition

  • Mixing is defined as an unit operation in which two or more components are treated in such a way  that each particle / molecule of the components lies as nearly as possible in contact with a particle / molecule of the other components.

  • If this is achieved it produces a theoretical ‘ideal’ situation, called a perfect mix.


Mechanisms of mixing:

Mechanisms of Solid Mixing:

  • Solids are mixed using three mechanisms as follows,

    1. Convective Mixing.

    2. Shear Mixing.

    3. Diffusive Mixing.

  1. Convective Mixing:

  1. Also called “Macromixing”.

  • Involves transfer of a group of particles from one part of a powder bed to another part.

  1. Shear Mixing:

    • Formation of shear forces by using an agitator arm or a blast of air causes movement of particles.

  2. Diffusive Mixing: 

    • Also called “Micromixing”.

    • Involves distribution of particles over a newly formed surface.

    • In this the material is tilted causing the upper surface to come down due to gravity while smaller particles diffuse to the upper layer.

Mechanisms of Liquid Mixing:

  • The liquids are mixed by one or more than one of the following mechanisms,

    1. Bulk Transport.

    2. Turbulent Mixing.

    3. Laminar Mixing.

    4. Molecular Diffusion.

  1. Bulk Transport:

    • Involves movement of a large part of the system to another part.

    • Can be achieved using paddles and blades.

  2. Turbulent Mixing:

    • Mixing takes place due to the formation of turbulent flow.

    • In turbulent flow various smaller currents of different velocities are formed which further form smaller currents.

    • Due to this formation of dividing currents, the particle mixing takes place very efficiently.

    • Highly effective mechanism of mixing.

  3. Laminar Mixing:

    • Associated with highly viscous liquids.

    • The shear force is created which breaks the liquid interface allowing movement of particles between the liquid bodies.

  4. Molecular Diffusion:

    • Mixing takes place at molecular levels.

    • Diffusion of molecules takes place due to thermal motions of the particles.

    • This process can be described quantitatively by “Fick’s Law of Diffusion” which depends on the concentration gradient at different points.

Mechanisms of Semisolid Mixing:

  • The mechanisms involved depend on the nature of materials.

  • The more liquid material will follow mechanisms of liquid mixing while more solid material will follow mechanisms of solid mixing.

Commonly Asked Questions.

  1. Define Mixing. Write a note on mechanisms of Mixing.

Popular posts from this blog

Rate of Drying Curve.

  Definition Drying is defined as the removal of liquid from a product usually with application of heat. Rate of Drying Curve. Drying process can be divided into three periods Initial Adjustment Period. Constant drying rate period. First falling drying rate period. Second falling rate period. Initial Adjustment Period (A-B): Also called the “ Heating up” period . In this period the substance gets heat and increases in temperature. Drying has not yet started. Constant drying rate period (B-C): During this period the temperature of the solid and the rate of drying remain constant. The moisture evaporating from the surface is replaced by water diffusing from the interior of the solid at a rate equal t o the rate of evaporation.  The moisture content at the end of constant rate (point C) is referred to as the critical moisture content (CMC).  At CMC, dry spots start appearing and drying rate starts falling . First falling drying rate period (C-D): This period is also called ...

Heat Exchangers and Heat Interchangers.

  In pharmaceutical industries many types of equipments are used for transfer of heat, they can be classified as follows, Heat Exchangers. Heat Interchangers. Heat Exchangers: These devices are used for transferring heat from a fluid (Hot Gas or Steam) to another fluid (Liquid) through a metal wall. Heat Interchangers: These devices are used for transferring heat from a One liquid to another liquid or one gas to another gas through a metal wall. HEAT EXCHANGERS; The equipment used for heat transferring are known as heat exchangers. Some of the processes that involves heat transfer in pharmaceutical industries are: Preparation of starch paste (in steam jacketed kettle). Crystallization. Evaporation. Distillation.  Classification of heat exchangers On the basis of transfer of heat, heat exchangers are classified as: Direct transfer type:  The hot and cold fluids are separated by a metal wall through which the heat is transferred from hot fluid to cold fluid. E.g. shell and ...

Flash Distillation.

  Principle: When a hot mixture is allowed to enter from a high-pressure zone into a low pressure zone, the entire liquid mixture is suddenly vaporized. This process is known as flash vaporization .  During this process, the chamber is cooled.  The less volatile fraction is condensed and the more volatile component remains in the vapor phase .  This process requires time, hence liquid and vapor are kept in intimate contact until equilibrium is achieved. Flash distillation is also called equilibrium distillation because separation of two liquids takes place when liquid and vapor phases are at equilibrium. Equipment used for Flash Distillation: Construction: It consists of a pump, which is connected to a feed reservoir.  Pumps help in pumping the feed into the heating chamber.  The heating chamber is heat supplied by steam.  The other end of the pipe is directly introduced into the vapor-liquid separator through a reducing valve.  The vapor outlet...