MCQs on Preformulation

MCQs on Preformulation

Quiz

  

Time for this test is 45 minutes.

 

1. Preformulation is about ensuring,
   1.   Stability
   2.   Safety
   3.   Efficacy
   4.   All of the above
2. Amorphous form shows,
   1.   Good solubility
   2.   Poor solubility
   3.   Long range order
   4.   None of the above
3. Crystal form shows this structure,
   1.   3D
   2.   2D
   3.   Short range
   4.   None of the above
4. In simple cubic crystal the faces are,
   1.   All unequal
   2.   Two equal one unequal
   3.   All equal
   4.   None of the above
5. Two or more molecules are hydrogen bonded to each other are called,
   1.   Crystals
   2.   Cocrystals
   3.   Polymorph
   4.   All of the above
6. DSC is,
   1.   Differential scanning calorimetry
   2.   Differential scattering calorimetry
   3.   Digital scanning calorimetry
   4.   None of the above
7. X ray diffraction pattern indicate,
   1.   Solubility
   2.   Crystallinity
   3.   Functional groups
   4.   Permeability
8. SEM can analyze,
   1.   Shape & Size
   2.   Crystallinity & Solubility
   3.   Complexation
   4.   Flow property
9. Bragg’s law defines the,
   1.   Shape
   2.   Solubility
   3.   Diffraction
   4.   All of the above
10. Crystal form shows,
    1.   Short duration of action
    2.   Rapid duration of action
    3.   Short onset of action
    4.   Long duration of action.
11. The ability of a substance to exist as two or more crystalline phases with different arrangements of molecules in crystal lattice is,
    1.   Cocrystal
    2.   Crystal
    3.   Polymorphism
    4.   None of the above
12. Estrone shows how many polymorphs,
    1.   4
    2.   2
    3.   3
    4.   None
13. Polymorphs differ in,
    1.   Physical properties
    2.   Chemical Properties
    3.   A & B both
    4.   None of the above
14. Enantiotropic polymorph can change in to another form,
    1.   reversibly
    2.   irreversibly
    3.   does not change
    4.   None of the above
15. The change between the two forms is irreversible in the type of polymorph,
    1.   Enantiotropic
    2.   Monotropic
    3.   A & B both
    4.   None of the above
16. Hydrates and solvates are called,
    1.   Polymorph
    2.   Pseudopolymorph
    3.   Cocrystals
    4.   None of the above
17. Coulter Counter can analyze,
    1.   Size distribution
    2.   Crystallinity & Solubility
    3.   Number of functional groups
    4.   Flow property
18. Most advanced particle size analysis technique is,
    1.   SEM
    2.   DLS
    3.   XRPD
    4.   Sieving
19. Micronization increases,
    1.   Size
    2.   Surface area
    3.   Bioactivity
    4.   Duration of action
20. Water solubility of API is needed for,
    1.   Formulation development
    2.   Dissolution into GI fluid
    3.   A & B both
    4.   None of the above
21. For good bioavailability what is needed,
    1.   Good solubility
    2.   Good Permeability
    3.   Good solubility poor permeability
    4.   Good solubility, good permeability.
22. Less soluble salts are intentionally used for
    1.   Increasing drug release
    2.   Masking taste
    3.   Protecting the parent drug from degradation
    4.   B & C both.
23. Which salt is used most widely in Pharma Industry,
    1.   Hydrochloride
    2.   Sodium
    3.   Potassium
    4.   Sulphate
24. Solubility can be improved by,
    1.   Cyclodextrin complexation
    2.   Salt formation
    3.   Solid dispersion
    4.   All of the above
25. The solubility of the pure form of API is determined by,
    1.   Partition coefficient
    2.   Phase Solubility Study
    3.   Permeability study
    4.   All of the above