MCQs: Microbial Spoilage & Preservation of Pharmaceuticals.

 

MCQs: Microbial Spoilage & Preservation of Pharmaceuticals.

Quiz

  

Atttempt as many times u like within 45 minutes.

 

1. Identify the method NOT USED to determine “Total Aerobic Microbial Count” of a test sample as per I.P.
   1.   Membrane Filtration
   2.   Plate Count Method
   3.   Measurement of Cell Nitrogen
   4.   Most Probable Number
2. Formulation can be protected from microbial attack by lowering their water activity with,
   1.   Drying
   2.   By addition of dilute HCL
   3.   Softening
   4.   Cooling
3. Which of the following is used as a test for “Bacterial Endotoxins”.
   1.   Rabbits Test for Pyrogens
   2.   Sterility Test
   3.   Most Probable Number
   4.   LAL Test
4. For Membrane filtration method in Total Viable Count, filter 50 mm in diameter and pore size not greater than ----- is used.
   1.   0.45µm
   2.   0.55µm
   3.   0.65µm
   4.   0.75µm
5. Which of the following Plate Count Methods produces “SubSurface Colonies”?
   1.   Pour Plate Method.
   2.   Spread Plate Method.
6. Which of the following methods used to determine Total Aerobic Microbial Count is with least accuracy?
   1.   Membrane Filtration.
   2.   Pour Plate Method.
   3.   Spread Surface Method.
   4.   Most Probable Number.
7. Which of the following methods used to determine Total Aerobic Microbial Count is also called the “Multiple Tube Method”?
   1.   Membrane Filtration.
   2.   Pour Plate Method.
   3.   Spread Surface Method.
   4.   Most Probable Number.
8. Escherichia coli produces which colored colonies on MacConkey’s Agar?
   1.   Jet Black Color.
   2.   Pink Color.
   3.   Yellow Color.
   4.   Colorless.
9. Salmonella typhi produces which color colonies on Wilson Blair Bismuth Sulphite medium?
   1.   Jet Black Color.
   2.   Pink Color.
   3.   Yellow Color.
   4.   Colorless.
10. Staphylococcus aureus produces which color colonies on Blood Agar?
    1.   Shiny Black Color.
    2.   Pink Color.
    3.   Yellow Color.
    4.   Colorless.
11. Staphylococcus aureus produces which color colonies on Mannitol Salt Agar?
    1.   Shiny Black Color
    2.   Pink Color
    3.   Yellow Color
    4.   Colorless
12. Pseudomonas aeruginosa produces which color colonies on MacConkey’s Agar?
    1.   Jet Black Color
    2.   Pink Color
    3.   Pale Yellow Color
    4.   Colorless
13. Which of the following microorganisms is identified by production of fluorescent pigments?
    1.   Pseudomonas aeruginosa.
    2.   Staphylococcus aureus
    3.   Salmonella typhi
    4.   Escherichia coli
14. Bluish-green coloration of colonies is characteristic of,
    1.   Pseudomonas aeruginosa
    2.   Staphylococcus aureus
    3.   Salmonella typhi
    4.   Escherichia coli
15. Causative organism of Gas Gangrene is,
    1.   Pseudomonas aeruginosa
    2.   Staphylococcus aureus
    3.   Clostridium septicum
    4.   Escherichia coli
16. Which of the following media is used for isolation of Candida albicans?
    1.   MacConkey’s Agar
    2.   Sabourd Dextrose Agar
    3.   Mannitol Salt Agar
    4.   Wilson Blair Bismuth Sulphite Medium
17. Which of the following media is used for cultivation of Salmonella typhi?
    1.   MacConkey’s Agar
    2.   Sabourd Dextrose Agar
    3.   Mannitol Salt Agar
    4.   Wilson Blair Bismuth Sulphite Medium
18. A raw materials obtained from mineral origin are most likely be contaminated with,
    1.   Pseudomonas aeruginosa
    2.   Staphylococcus aureus
    3.   Clostridium septicum
    4.   Escherichia coli
19. Salmonella paratyphi produces which color colonies on Wilson Blair Bismuth Sulphite medium?
    1.   Jet Black Color
    2.   Pink Color
    3.   Yellow Color
    4.   Green Color
20. Which of the following microorganisms is non motile?
    1.   Pseudomonas aeruginosa
    2.   Staphylococcus aureus
    3.   Clostridium septicum
    4.   Salmonella typhi
21. Identify the microorganism not used in the Challenge Test for preservative
    1.   Pseudomonas aeruginosa
    2.   Staphylococcus aureus
    3.   Mycobacterium leprae
    4.   Candida albicans
22. Identify the mould used in the Challenge Test for preservatives as per IP 2014.
    1.   Candida albicans
    2.   Aspergillus brasiliansis
    3.   Penicillium notatum
    4.   Saccharomyces cerevisiae
23. In Challenge Test for Preservatives effect of preservative is examined maximum upto,
    1.   2 days.
    2.   7 days.
    3.   14 days.
    4.   28 days.
24. In Challenge Test for Preservatives effect of preservative is examined minimum upto,
    1.   2 days.
    2.   7 days.
    3.   14 days.
    4.   28 days.
25. Which of the following is used as a preservative in tablets?
    1.   Methyl Paraben
    2.   Bronopol
    3.   Cetyltrimethylammonium Bromide
    4.   Chlorocresol
26. Concentration of Methyl Paraben used as preservative in tablets is,
    1.   0.1 %W/V
    2.   0.01 %W/V
    3.   0.5 %W/V
    4.   0.05 %W/V
27. Often preservatives are combined to achieve synergy in action, in what ratio Methyl para hydroxybenzoic acid is combined with propyl para hydroxybenzoic acid?
    1.   10:1
    2.   1:10
    3.   2:10
    4.   10:2
28. Concentration of Benzyl Alcohol used as preservative in injectables is,
    1.   1.0-2.0 %W/V
    2.   1.5-2.5 %W/V
    3.   10-20 %W/V
    4.   15-25 %W/V