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Renin Angiotensin Mechanism.

Clean area classification.

  Clean area classification.

  • The clean or buffer room is the secondary engineering control. 

  • It houses the primary engineering controls (the LAFH, BSC, or CA) where the aseptic compounding is actually performed. 

  • Clean room is a specially constructed enclosed area, which contains one or more clean zones, where the concentration of airborne particles is controlled using HEPA filters, continuous air circulation, and a physical barrier to non-filtered (or outside) air. 

  • Clean rooms establish appropriate environmental levels for airborne particulates, temperature, humidity, air pressure, and airflow patterns. 

  • Clean rooms are categorised by their constant air quality or class. 

Clean rooms are rated as given in table:  

(Lower the classification number, cleaner is the air.)

Clean Room 

Properties

Class 10,000 (ISO class 7)

10,000 or less particles of 0.5 µ and larger size exist in a given cubic foot of air. 

Class 1,000 (ISO class 6) 

1,000 or less particles of 0.5 µ and larger size exist in a given cubic foot of air. 

Class 100 (ISO class 5) 

100 or less particles of 0.5 µ and larger size exist in a given cubic foot of air.  


  • Apart from the above mentioned basic components, a clean room also includes: 

    • 1) UV irradiation, 

    • 2) Air-lock entry portals, 

    • 3) Special filtration or treatment systems for incoming air, 

    • 4) Sticky mats for removing particulate matter from shoes, and 

    • 5) Positive room air pressure for controlling entry of contaminants from adjacent rooms.

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