Introduction: In our environment microbes are present everywhere i. Air, water, soil etc. These microbes are to cause spoilage of not only food products but also pharmaceutical products. The spoilage of pharmaceutical products can result in serious health hazards to the consumers as well as cause financial problems to the manufacturers. Pharmaceutical products are considered microbiologically spoiled when even low levels of pathogenic microbes or toxic microbial metabolites are present and detectable physical or chemical change have been noted in the product . In short microbial spoilage of pharmaceuticals can be defined as deterioration of pharmaceutical products due to microbial contamination . Sources and Types Of Contamination: Contaminants can gain entry into a production process stream from several sources such as, Personnel, Poor facility design, Incoming ventilation air, Machinery and other equipment for production, Raw material and semi-finished material, Packa
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