MCQs: Nasopulmonary Drug Delivery Systems.

Multiple Choice Questions on "Nasal and Pulmonary Drug Delivery Systems".

MCQs: Nasopulmonary Drug Delivery Systems.

Quiz

  

Atttempt as many times u like within 45 minutes.

 

1. Which of the following is a disadvantage of Nasopulmonary Drug Delivery Systems.
   1.   Large drug loss.
   2.   Contact Dermatitis.
   3.   Gastritis
   4.   Increased first pass effect.
2. What describes the “Upper Airway”.
   1.   Nasopharyngeal Region.
   2.   Tracheobronchial Region.
   3.   Alveolar Region.
   4.   Tracheoalveolar Region.
3. Nasal administration is commonly used for the relief of?
   1.   Headache
   2.   Cough
   3.   Sore throat
   4.   Congestion
4. In ancient Ayurvedic time the preparations and dosage forms for nasal drug delivery were called,
   1.   Basti
   2.   Nasya
   3.   Churna
   4.   Avaleha
5. Which of the following drug candidates does not suits for Nasopulmonary drug delivery system,
   1.   Drug showing extensive first pass metabolism.
   2.   Drug with irritant action.
   3.   Drug with poor gastrointestinal stability.
   4.   Drugs need to be targeted for CNS by avoiding Blood Brain Barrier.
6. Inhalables provide for very rapid onset of action similar to the i.v. route.
   1.   True
   2.   False
7. Normal pH of the nasal secretions in adult is,
   1.   7.5-8.5
   2.   5.5-6.5
   3.   7-8
   4.   5-6
8. The mechanism by which the peptides are absorbed in nasal cavity is,
   
   1.   Paracellular (Intercellular).
   2.   Trancytotic
   3.   Transcellular
   4.   All of the above.
9. Nasal drops is considered as one of the most simple and convenient systems has a significant disadvantage,
   1.   Lacks precision.
   2.   Dose dumping.
   3.   Erythema
   4.   Thrombophlebitis
10. Liposomes can be used in Nasal Solutions however, their size should not be more than,
    1.   50 microns.
    2.   40 microns
    3.   30 microns
    4.   35 microns
11. Bile salts like Sodium deoxycholate, sodium glycocholate are used in Nasal drug delivery systems as a,
    1.   Propellent
    2.   Bioadhesives
    3.   Permeation enhancers
    4.   Antiallergics
12. Which of the following is not applicable for Nasal Gels?
    1.   Mucoadhesive testing.
    2.   In vitro drug diffusion study
    3.   Measurement of Gelation Temperature (T1) and Gel Melting Temperature (T2)
    4.   Hardness Testing
13. “Nasal clearance” on of the major problem affecting performance of a Nasal drug delivery system can be reduced by use of,
    1.   Starch microspheres.
    2.   Chitosan
    3.   Bile Salts
    4.   Only A & B
14. Which of the following is not an advantage of the Pulmonary drug delivery system.
    1.   Noninvasive
    2.   Dose required is lower than oral dose
    3.   Faster onset of action
    4.   Can target CNS transport by avoiding Blood Brain Barrier
15. Protein stability in the formulation is a major issue with Pulmonary Drug Delivery System, it can be addressed by adding “Surfactants” which act by,
    1.   Reducing protein aggregation.
    2.   Forms protective complexes
    3.   Decreases their absorption
    4.   Prevent coagulation
16. Which of the following inhalers has a greater efficiency?
    1.   Dry Powder Inhalers (DPIs).
    2.   Pressurized Metered Dose Inhalers (pMDIs).
    3.   Nebulizers
    4.   A & C
17. Dry powder inhalers(DPI) are a solid particle blend containing drug with particle size,
    1.   less than 3µm
    2.   less than 4µm
    3.   less than 5µm
    4.   less than 6µm
18. Which of the following is not an advantage of Dry powder inhalers(DPI)?
    1.   Propellent Free.
    2.   Greater dose accuracy.
    3.   Greater chemical stability.
    4.   Lesser formulation problems.
19. Metered Dose Inhalers (MDI) has a following known drawback,
    1.   Lesser dose accuracy.
    2.   Can not deliver higher doses.
    3.   Only single dose dispensers are available.
    4.   Only useful for potent drugs.
20. Which of the following is a preferred carrier in Dry powder inhalers(DPI)?
    1.   Lactose
    2.   Sucrose
    3.   Talc
    4.   Boric Acid