MCQs: Liposomes

MCQs: Liposomes

Quiz

  

Atttempt as many times u like within 45 minutes.

 

1. Liposomes have ----- shape,
   1.   Spherical
   2.   Triangular
   3.   Hexagonal
   4.   Compact Squares
2. Diameter of liposomes is in the following range ---,
   1.   15 nm to 1000 nm
   2.   15 nm to 100 nm
   3.   150 nm to 1000nm
   4.   150 nm to 850 nm
3. Liposomes are spherical structures made up of bilayer of,
   1.   Hydrophilic substances.
   2.   Hydrophobic Substances
   3.   Only A
   4.   Both A & B
4. Liposomes are well known for their ------ half life.
   1.   Shorter
   2.   Extended
   3.   Intermediate
   4.   Both A & B.
5. Liposomes have ------ water solubility.
   1.   Lower
   2.   Higher
   3.   Intermediate
   4.   Both B & C
6. Liposomes are made up of,
   1.   Phospholipids
   2.   Glycoproteins
   3.   Polysaccharides
   4.   Monosaccharides
7. “Pauci-lamellar Liposomes” contain ----- number of lamellas,
   1.   Lower
   2.   Higher
   3.   Intermediate
   4.   None
8. Drug loading during or before the process is called ----,
   1.   Active loading.
   2.   Passive loading.
9. Drug loading after the process is called ----,
   1.   Active loading.
   2.   Passive loading.
10. Which of the following is a major drawback of “Lipid Hydration” method?
    1.   Smaller internal volume.
    2.   Higher encapsulation efficiency.
    3.   Non uniform size distribution.
    4.   Higher internal Volume.
11. Which of the following is an example of natural phospholipid,
    1.   Dioleoylphosphatidylcholine (DOPC)
    2.   Distearoylphosphatidylcholine (DSPC)
    3.   Phosphatidylethanolamine
    4.   Dioleoylphosphatidylethanolamine (DOPE)
12. Which of the following is an example of synthetic phospholipid,
    1.   Dioleoylphosphatidylcholine (DOPC)
    2.   Phosphatidylserine
    3.   Phosphatidylethanolamine
    4.   Phosphatidylcholine
13. Which of the following is not an advantage of Liposomes.
    1.   Tissue targeting
    2.   Increased therapeutic index.
    3.   Reduction in drug toxicity.
    4.   Faster dissolution.
14. Small Unilamellar Vesicles (SUVs) show diameter in the following range,
    1.   Approximately 20 nm to 100 nm.
    2.   Approximately 20 nm to 1000 nm.
    3.   Approximately 50 nm to 100 nm.
    4.   Approximately 50 nm to 1000 nm.
15. Identify the wrong statement regarding Liposomes,
    1.   They are colloidal in structure and their handling is very critical.
    2.   They have stability issues.
    3.   They have shorter half lives.
    4.   They are not site specific.
16. 16) The composition of liposomes involve Phosphatidylglycerol, Cholesterol and Phosphatidylcholine in the ------- proportion,
    1.   0.1:1:0.9
    2.   1:0.1:0.9
    3.   1:1:0.9.
    4.   0.1:1:01
17. Which of the following is / are disadvantage /s of “Probe Sonication” method?
    1.   Degradation of Proteins.
    2.   Metal contamination.
    3.   Smaller entrapment.
    4.   All of the above.
18. One of the fastest methods to obtain “Multi Lamellar Vesicles” is Ethanol injection, identify drawbacks of the technique.
    
    1.   Azeotrope formation with water.
    2.   Coagulation of proteins.
    3.   Bad smell.
    4.   Both A & B.
19. Membrane extrusion technique is used to…..,
    1.   Reduce size of Liposomes.
    2.   Increase entrapment efficiency of liposomes.
    3.   Increase their Half life.
    4.   None of the above.
20. Which of the following is the most specific method for determination of liposomal size.
    1.   Electron microscopy.
    2.   Laser Light Scattering.
    3.   Light Microscopy.
    4.   Fluorescence microscopy.