Definition: Size Separation is a pharmaceutical process by which the particles of different sizes are separated from a mixture. Also called as, Sifting. Sieving. Classifying. Screening. Applications: As a method to determine particle size and size distribution, which are useful in the production of tablets and capsules. As a quality control tool for the analysis of raw materials such as griseofulvin and aspirin. To test the efficiency of a size reduction equipment or process. To optimize the process conditions such as method of agitation, time of screening, feed rate etc. Official Standards of Sieves: Indian Pharmacopoeia has prescribed standards for powders for pharmaceutical purposes. Accordingly, degree of coarseness or fineness is expressed with reference to the nominal aperture size of sieve through which powder is able to pass. The IP 1996 specifies five grades of powders. Sr. No. Grade of Powder Sieve through which all particles must pass Nominal Mesh Aperture Size
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